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Abstract Emerging evidence from clinical and experimental studies has suggested potential associations between artificial food pigments like Sunset Yellow (SY) and allergic reactions, though their mechanistic contributions remain unclear. This study investigated the immunological and epithelial effects of the synthetic pigment SY using a translational approach integrating mouse model assays.
Inhibition of the hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) represents a promising strategy for discovering next-generation treatments for renal anemia. We discovered DS44470011 in our previous study, which showed potent in vitro activity and in vivo efficacy based on HIF-PHD inhibition. However, DS44470011 was also found to exert genotoxic effects.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
