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Dinuo Li on Muck Rack

Dinuo Li

As seen in: Frontiers in Immunology
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Articles

Carnosic acid alleviates 5-Fluorouracil chemoresistance and enhances CD8 + T cell cytotoxicity in gastric cancer by regulating the CXCL12/CXCR7 axis

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By Yinan Zhang, Xin Zhang, Dinuo Li
| Frontiers in Immunology
Abstract Background: Key features of gastric cancer (GC) include its aggressive nature, high metastatic capability, and a tendency for relapse. While 5-fluorouracil (5-FU) remains a cornerstone of GC treatment, its efficacy is substantially undermined by the emergence of acquired drug resistance. Carnosic acid (CA) has antitumor and immunomodulatory potential, but its role in 5-FU-resistant GC remains unclear.
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