Div. Integrative Nutriomics on Muck Rack

Div. Integrative Nutriomics

As seen in: The Journal of Biological Chemistry
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Articles

Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background

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By Masashi Muramatsu, Tsuyoshi Osawa, Div. Molecular, Div. Integrative Nutriomics
| The Journal of Biological Chemistry Verified
Abstract Down syndrome critical region (DSCR)-1 functions as a feedback modulator for calcineurin- nuclear factor for activated T cell (NFAT) signals, which are crucial for cell proliferation and inflammation. Stable expression of DSCR-1 inhibits pathological angiogenesis and septic inflammation. DSCR-1 also plays a critical role in vascular wall remodeling associated with aneurysm development that occurs primarily in smooth muscle cells.
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