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Doğuş Altunöz on Muck Rack

Doğuş Altunöz

As seen in: Nature
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Articles

Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8 + T cell differentiation

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By Kaushikk Ravi Rengarajan, Nikos E. Papaioannou, Sadiq Nasrah, Jessica Vetters, Maria Richter, Maria Reyes, Denise Messerer, Melanie Schmid, Tobias Straub, Michele Proietti, Katrin Böttcher, Maria Colomé-Tatché, Dirk Haller, Jan P. Böttcher, Stephanie Ganal-Vonarburg, Sophie Janssens, Christian Schulz, Anne Krug, Barbara U. Schraml, Doğuş Altunöz, Ramin Shakiba, Hamsa Narasimhan, Nadine Nuschele, Sabine Schwamberger, Andreas Goschin, Dimitrios Starfas
| Nature Verified
Abstract Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis. Instructed by environmental signals, type 1 conventional dendritic cells (cDC1) contribute to both processes but how the balance may be achieved is unclear. Here, we uncover an interferon (IFN)γ-driven regulatory circuit in early life that relays dietary cues to spleen cDC1.
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