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Barbara U. Schraml on Muck Rack

Barbara U. Schraml

As seen in: Nature, Science Magazine, Cell Reports
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Articles

Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8 + T cell differentiation

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By Kaushikk Ravi Rengarajan, Nikos E. Papaioannou, Sadiq Nasrah, Jessica Vetters, Maria Richter, Maria Reyes, Denise Messerer, Melanie Schmid, Tobias Straub, Michele Proietti, Katrin Böttcher, Maria Colomé-Tatché, Dirk Haller, Jan P. Böttcher, Stephanie Ganal-Vonarburg, Sophie Janssens, Christian Schulz, Anne Krug, Barbara U. Schraml, Doğuş Altunöz, Ramin Shakiba, Hamsa Narasimhan, Nadine Nuschele, Sabine Schwamberger, Andreas Goschin, Dimitrios Starfas
| Nature Verified
Abstract Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis. Instructed by environmental signals, type 1 conventional dendritic cells (cDC1) contribute to both processes but how the balance may be achieved is unclear. Here, we uncover an interferon (IFN)γ-driven regulatory circuit in early life that relays dietary cues to spleen cDC1.
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GM-CSF and specific type 2 cytokines induce CD103+ and CD301b+ cell states in cDC1s and cDC2s

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By Lukas Amon, Damir Vurnek, Anna Seichter, Giorgi Tchitashvili, Tomasz Kaszubowski, Nincy Debeuf, Tina Vogler, Lukas Lächele, Anna Baranska, Stella E. Autenrieth, Falk Nimmerjahn, Kai Hildner, Klaus Pfeffer, Barbara U. Schraml, Lukas Heger, Bart N. Lambrecht, Christian Lehmann, Diana Dudziak, Markus Mroz, Nicole Küpper, Kaushikk Ravi Rengarajan, Nounagnon R. Tochoedo
| Cell Reports Verified
Keywords conventional dendritic cells ontogeny cell state CD103+ cDC1 CD301b+ cDC2 DC2 and DC3 progenitor heterogeneity type 2 cytokines CD301b GM-CSF Research topic(s) CP: immunology Introduction Conventional dendritic cells (cDCs) represent central orchestrators of immune responses. cDCs were classified based on ontogeny, phenotype, and function into cDC1s and cDC2s across murine and human tissues.1 They arise from hematopoietic stem cells (HSCs) located in bone marrow.
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Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses - Nature Communications

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By Hongkui Xiao, Isabel Ulmert, Ilia Kurochkin, Yinshui Chang, Urs Mörbe, Carlos-Filipe Pereira, Barbara U. Schraml, Dirk Baumjohann, Signe Holst
| Nature Verified
Abstract Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters the phenotype and transcriptome of cDC1 and cDC2, while their lineage identity is preserved.
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