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Dominguez Crespo Hirata on Muck Rack

Dominguez Crespo Hirata

As seen in: Frontiers, Frontiers in Immunology
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Articles

Long non-coding RNAs in response to Ebola virus vaccine-induced immunity

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By Isabelle Franco, Dominguez Crespo Hirata, Strategic Alliances, Sahlgrenska Academy
| Frontiers in Immunology
Introduction Ebola virus disease (EVD) caused by Orthoebolavirus zairense is a severe hemorrhagic fever with a fatality rate ranging from 50% to 90%. The disease is highly contagious, and from 2014 to 2016, an Ebola outbreak in West Africa killed over 11,000 people, while between 2018 and 2020, the outbreak in the Democratic Republic of Congo (DRC) resulted in 3,323 cases and 2,299 deaths.
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Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts

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By Gonzalez Carvalho, Dominguez Crespo Hirata, Mano Alves, Patrícia Conceição
| Frontiers
1 Introduction Ebola virus disease (EVD) is a severe and fatal infectious disease (1). rVSVΔG-ZEBOV-GP, under the name of Ervebo®, is given as a single-dose vaccine. It is a recombinant vaccine against the live and attenuated vesicular stomatitis (VSV) virus, in which the gene encoding for the VSV envelope glycoprotein has been replaced by the Ebola strain Zaire virus (ZEBOV-GP) glycoprotein gene (2). This vaccine is highly immunogenic for at least two years (3).
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