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Gonzalez Carvalho

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Articles

Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts

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By Gonzalez Carvalho, Dominguez Crespo Hirata, Mano Alves, Patrícia Conceição
| Frontiers
1 Introduction Ebola virus disease (EVD) is a severe and fatal infectious disease (1). rVSVΔG-ZEBOV-GP, under the name of Ervebo®, is given as a single-dose vaccine. It is a recombinant vaccine against the live and attenuated vesicular stomatitis (VSV) virus, in which the gene encoding for the VSV envelope glycoprotein has been replaced by the Ebola strain Zaire virus (ZEBOV-GP) glycoprotein gene (2). This vaccine is highly immunogenic for at least two years (3).
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