Dominique Ramirez

Get full text access Log in, subscribe or purchase for full access. References 1. Mitrea, D.M. ∙ Kriwacki, R.W. Phase separation in biology; functional organization of a higher order Cell Commun. Signal. 2016; 14:1 2. Laflamme, G. ∙ Mekhail, K. Biomolecular condensates as arbiters of biochemical reactions inside the nucleus Commun. Biol. 2020; 3:773 3. O’Flynn, B.G. ∙ Mittag, T. The role of liquid–liquid phase separation in regulating enzyme activity Curr. Opin. Cell Biol. 2021; 69:70-79 4. Boeynaems, S.

Abstract Liquid-liquid phase separation (LLPS) is one mechanism that cells can use to organize biomolecules spatially and functionally. Some coiled-coil (CC) proteins, such as the centrosomal proteins pericentrin and spd-5, are thought to LLPS, but it is currently unknown what parts of these proteins facilitate the process. It is thought, however, that the numerous CC domains in these proteins might be contributing to their LLPS.

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