Donald E. Ingber on Muck Rack

Donald E. Ingber

  • Lead Researcher and Director, Wyss Institute for Biologically Inspired Engineering, Harvard
As seen in: Color Research & Application, Nature, Wiley, British Pharmacological Society, Harvard University, JAMA (The Journal of the American Medical Association), JAMA Network, Science Magazine, Royal Society of Chemistry, Cell Press and
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Articles

Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae

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By Melis N. Anahtar, Dimitra Karagkouni, Youssif M. Ali, Jacqueline Valeri, Seyed Majed Modaresi, Aarti Krishnan, Nina Donghia, Erica J. Zheng, Aakanksha Gulati, Alicia Grattan Jorgenson, Abidemi Junaid, Parijat Bandyopadhyay, Andreas Luttens, Krishna V. Suresh, Paige Edwards, Felix Wong, Yu ZHANG, Danilo Ritz, Edmund Loh, Massimiliano Gaetani, Marie-Stephanie Aschtgen, Amir Ata Saei, Yonatan H Grad, Donald E. Ingber, Margaux Gaborieau
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Neisseria gonorrhoeae, a well-known cause of sexually transmitted disease, has grown increasingly treatment resistant, and identifying effective ways to tackle this pathogen is an utmost priority. Here, Anahtar et al.
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Probiotic intervention mitigates radiation-induced intestinal injury by alleviating oxidative stress in a human gut-on-a-chip

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By Tadanori Mammoto, Donald E. Ingber, Hyun Kim
| Nature Verified
Abstract Gastrointestinal acute radiation syndrome (GI-ARS) poses a critical public health concern, necessitating the development of effective medical countermeasures (MCM). Here, we evaluated the therapeutic potential of a commercially available probiotic formulation using a human gut-on-a-chip model that mimics the physiodynamic intestinal microenvironment. Intestinal epithelial Caco-2 cells were subjected to 8 Gy gamma radiation, targeting the epithelial layer, the culture medium, or both.
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Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects

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By Alican Ozkan, Gwenn E. Merry, David Chou, Ryan R. Posey, Anna Stejskalová, Karina Salgado Calderon, Megan M Sperry, Joshua Piatok, Viktor Horváth, Lorenzo Ferri, Emanuela Carlotti, Stuart Mcdonald, Douglas J. Winton, Rocco Ricciardi, Liliana Bordeianou, Sean Hall, Girija Goyal, Donald E. Ingber
| Nature Verified
Abstract Patients affected by inflammatory bowel disease (IBD) exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis and cancer risk, with symptoms often being exacerbated in women during pregnancy.
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