Dong-ming Zhang on Muck Rack

Dong-ming Zhang

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Articles

Triptolide derivative STP1 ameliorates murine systemic lupus erythematosus via targeting Fyn kinase - Acta Pharmacologica Sinica

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By Yu Zhou, Hao-Wen Luo, Yi-fan Feng, Lei Wu, Ying-Da Zang, Tian-Tai Zhang, Qiao-yi Ding, Ya-zi Wei, Dong-ming Zhang, Cheng-juan Chen
| Nature Verified
Abstract Triptolide has demonstrated potent immunosuppressive properties in multiple autoimmune disorders, but its severe toxicity has greatly hampered clinical application. Here, we synthesized a triptolide derivative STP1, which exhibits remarkably reduced toxicity compared with triptolide. Immune dysfunction plays a critical role in systemic lupus erythematosus (SLE), an archetypical and refractory autoimmune disorder with limited therapeutic options and suboptimal outcomes.
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