Ying-Da Zang

Abstract Triptolide has demonstrated potent immunosuppressive properties in multiple autoimmune disorders, but its severe toxicity has greatly hampered clinical application. Here, we synthesized a triptolide derivative STP1, which exhibits remarkably reduced toxicity compared with triptolide. Immune dysfunction plays a critical role in systemic lupus erythematosus (SLE), an archetypical and refractory autoimmune disorder with limited therapeutic options and suboptimal outcomes.

1. Introduction Click to copy section linkSection link copied! Cisplatin, a widely used chemotherapeutic agent for the treatment of several solid tumors, shows adverse effects in normal tissues and organs, especially nephrotoxicity, limiting its clinical application. The manifestations of cisplatin nephrotoxicity include acute kidney injury (AKI), hypomagnesemia, hypocalcemia, hyperuricemia, and thrombotic microangiopathy.