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Dongyin He on Muck Rack

Dongyin He

As seen in: Nature, The Journal of Clinical Investigation
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Articles

Analysis of the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins using snFLARE-seq and mxFRIZNGRND - Nature Communications

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By Dongyin He, Haoran Hu, Kai Xiao, Yuhang Zhang, Yongbing Cheng, Shaozhuo Jiao, Yimei Hao, Yuanyuan Cai, Ziqun Liu, Xinran Yan, Qinsheng Chen, Xiyan Mu, Qi Wang, Shan Peng, Xiaoling Zhi, Qing Ye, Yuyao Yang, Meixia Che, Shengsong Huang, Hongqian Guo, Luonan Chen, Huiru Tang, Xuefeng Qiu, Guoqin Sang, Yanxia Chang
| Nature Verified
Abstract Prostate cancer cells of different anatomical locations display remarkable heterogeneity. This poses a challenge to the clinical relevance of pre-clinical models and the efficacy of contemporary therapeutic approaches. Here we develop the snFLARE-seq and mxFRIZNGRND methodologies to directly investigate the transcriptomic and metabolomic landscape of prostate cancer patients utilizing formalin-fixed paraffin-embedded (FFPE) specimens.
Open in Who Shared Issue with article?

Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer

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By XueBin Zhang, Zengming Wang, Shengsong Huang, Dongyin He
| The Journal of Clinical Investigation
Abstract Strategies for patient stratification and early intervention are required to improve clinical benefits for patients with prostate cancer. Here, we found that active DHEA utilization in the prostate gland correlated with tumor aggressiveness at early disease stages, and 3βHSD1 inhibitors were promising for early intervention. [3H]-labeled DHEA consumption was traced in fresh prostatic biopsies ex vivo.
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