Skip to main content
Donjete Simnica on Muck Rack

Donjete Simnica

As seen in: Nature, Cell Press
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Donjete

Contact Donjete, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours - Nature Biomedical Engineering

|
By Janina Dörr, Lisa Gregor, Sebastian Lacher, Arman Oner, Yi Sun, Ignazio Piseddu, Luisa Fertig, Stefanie Lesch, Stefanos Michaelides, Matthias Seifert, Adrian Gottschlich, Daria Briukhovetska, Donjete Simnica, Kathrin Gabriel, Sonia Cohen, Genevieve M. Boland, David Andreu-Sanz, Emanuele Carlini, Sophia Stock, Anne V. Holtermann, Philipp Müller Verified, Thaddäus Strzalkowski, Marcel P. Trefny, Stefan Endres, Russell Jenkins, Jan P. Böttcher, Sebastian Kobold, Sebastijan Spajic, Natasha Samson, Lina Majed, Viktoria Hartmann
| Nature Verified
Abstract The efficacy of chimeric antigen receptor (CAR) T cell therapy in solid cancers is limited by immunosuppression in the tumour microenvironment (TME). Prostaglandin E2 (PGE2) is a key factor locally inhibiting T cell function. We hypothesized that targeted ablation of PGE2 signalling in CAR T cells may enhance their activity in PGE2-rich solid tumours. Here we generate knockout CAR T cells double deficient for the PGE2 receptors EP2 and EP4 (EP2−/−EP4−/−) by CRISPR–Cas9 engineering.
Open in Who Shared Issue with article?

Landscape of T‐cell repertoires with public COVID‐19‐associated T‐cell receptors in pre‐pandemic risk cohorts

|
By Donjete Simnica, Christoph Schultheiß, Malte Mohme, Lisa Paschold
| Wiley Online Library Verified
Original Article Donjete Simnica, orcid.org/0000-0003-2286-1381 Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany Equal contributors.
Open in Who Shared Issue with article?

Responsiveness to Immune Checkpoint Inhibitors Is Associated With a Peripheral Blood T-Cell Signature in Metastatic Castration-Resistant Prostate Cancer | JCO Precision Oncology

|
By Donjete Simnica, Lorenzo Fanchi, Edith Willscher, Iris S.H. Kloots
| ascopubs.org
No companion articles DOI: 10.1200/PO.20.00209 JCO Precision Oncology no. 4 (2020) 1374-1385. Published online November 16, 2020.
Open in Who Shared Issue with article?
See all 5 articles