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Doug Barrick

As seen in: Nature, Wiley Online Library, ACS Publications, BioRxiv, Cell Press, Digital Courier
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Articles

Protein stability is determined by single-site bias rather than pairwise covariance

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By Matt Sternke, Katherine W. Tripp, Soumya Prakash Behera, Justin Nguyen, Doug Barrick
| Nature Verified
Abstract The biases revealed in protein sequence alignments have been shown to provide information related to protein structure, stability and function. Recent studies using Potts models show that single-site biases and pair correlations can improve predictions of protein fitness, activity and stability compared to simpler models.
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Rutherford approves housing, infrastructure projects

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By Doug Barrick
| Digital Courier Verified
The Rutherfordton Town Council met for its regular monthly session on Wednesday, October 1, taking action on several initiatives to strengthen housing, infrastructure, and community services. One of the key actions was the decision to call a public hearing on November 5 to consider expanding the boundaries of the Town’s popular Mint Social District to include Mountain Haze Beer Garden and Night Owl Iron Works.
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Thermodynamic Coupling in a Consensus-Designed Spectrin Repeat Protein

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By Mark Petersen, Soumya Prakash Behera, Ananya Majumdar, Doug Barrick
| ACS Publications
B: Biophysical and Biochemical Systems and ProcessesMay 5, 2025 Mark Petersen The T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States Soumya Prakash Behera The T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N.
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