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Doureradjou Peroumal on Muck Rack

Doureradjou Peroumal

As seen in: The Journal of Clinical Investigation
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Articles

Divergent stage-specific regulation of neutrophil function by glucose transporter 1 in murine antibody-mediated glomerulonephritis

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By JCI Insight, Hossein Rahimi, Wonseok Choi, Doureradjou Peroumal
| The Journal of Clinical Investigation
Abstract Prolonged and dysregulated neutrophilic inflammation causes tissue damage in chronic inflammatory diseases, including antibody-mediated glomerulonephritis (AGN). An increase in glycolysis, supported by enhanced glucose uptake, is a hallmark of hyperneutrophilic inflammation. Neutrophils upregulate glucose transporter 1–mediated (Glut1-mediated) glucose incorporation for renal antimicrobial activities.
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