Duncan E. Astle

INTRODUCTION Adolescence is a period of significant physical, social and neurocognitive development (Spear, 2000). This developmental period is also marked by an increased susceptibility to the onset of mental health problems, with the median age for the onset of all mental health problems occurring at 14.5 years (Solmi et al., 2022).

Abstract The Individual Brain Charting project focuses on collecting functional Magnetic Resonance Imaging data across a large set of cognitive tasks from a fixed cohort of participants, within a standardized environment. This approach seeks to obtain refined cognitive phenotyping of individual brains, uncovering details of their functional organization.

fronto-temporal cortex glioma plasticity prenatal connectivity transcriptomics Significance Statement Here we leveraged fetal neuroimaging and adult brain transcriptomes to investigate early and late differences between cortical regions. We present new evidence that already at mid-prenatal development, the fronto-temporal lobes are disproportionally connected to subcortical regions, potentially reflecting an early route to their establishment as integrative cortical centers.