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Duncan Smith

Solway Moss
As seen in: LinkedIn, Medium, The Athletic, BBC, Daily Mail, Forbes, Irish Daily Mail, Nature, The Daily Mirror, The Guardian and
Films, TV, cats, current affairs and Top of the Pops type music #TOTP Swiftie
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Articles

Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining

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By Zijuan Wang, Benjamin Foster, Yue Wu, Deepak Behera, Francesca Conte, Eleanor W. Trotter, Shweta Choudhary, Reuven Wiener, Petra Beli, Duncan Smith, William Banks, Steven C. Bagley, Shane McKee, Stefan Meyer, Amanda K. Chaplin, Wolfgang Dörner, Henning D. Mootz, Iain M. Hagan, Jeremy Stark, Igor Larrosa, Matthew J. Cliff, Christine Schmidt, Maria Jose Cabello-Lobato, Meenakshi Minnis, Yaron Galanty
| Nature Verified
Abstract Posttranslational modifications with ubiquitin-like modifiers (UBLs) are critical for genome maintenance, yet many remain mechanistically uncharacterised. Here, we identify UFM1 as a key regulator of non-homologous end-joining (NHEJ), a major DNA double-strand break repair pathway.
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Molecular and biological characterization of a newly discovered Kayfunavirus bacteriophage targeting multidrug-resistant Escherichia coli from swine feces

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By Phitchayapak Wintachai, Renuka Thonguppatham, Duncan Smith, Supayang Piyawan Voravuthikunchai, Sutthirat Sitthisak, Ratchadaporn Boripun, Martha Clokie, Komwit Surachat
| Nature Verified
Abstract Multidrug-resistant (MDR) Escherichia coli infections and their biofilms in swine and swine farms are a major concern due to their impact on animal health, economic losses, and the spread of antibiotic resistance. There is also increasing concern about the potential transmission of antibiotic resistance from animals to humans. To address these issues, alternative strategies to control E.
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Alternative enzymatic pathways to penicillin antibiotics

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By Puja Saha, Guangcai Xu, Deepanjan Panda, Duncan Smith, Luis Bering, Sarah Shepherd, Jason Micklefield, Sebastian Cuesta-Hoyos
| Nature Verified
Abstract The discovery of penicillin, more than a century ago, has been one of the most significant advances in medicine. Despite the growing threat of antimicrobial resistance, which has rendered many other antibiotics ineffective, penicillin derivatives remain among the most widely prescribed antibiotics. Penicillin is biosynthesised by a large nonribosomal peptide synthetase (NRPS) enzyme, which assembles a tripeptide precursor ACV.
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