Duncan Smith
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Articles by Duncan Smith
Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining
Abstract Posttranslational modifications with ubiquitin-like modifiers (UBLs) are critical for genome maintenance, yet many remain mechanistically uncharacterised. Here, we identify UFM1 as a key regulator of non-homologous end-joining (NHEJ), a major DNA double-strand break repair pathway.
Molecular and biological characterization of a newly discovered Kayfunavirus bacteriophage targeting multidrug-resistant Escherichia coli from swine feces
Abstract Multidrug-resistant (MDR) Escherichia coli infections and their biofilms in swine and swine farms are a major concern due to their impact on animal health, economic losses, and the spread of antibiotic resistance. There is also increasing concern about the potential transmission of antibiotic resistance from animals to humans. To address these issues, alternative strategies to control E.
Alternative enzymatic pathways to penicillin antibiotics
Abstract The discovery of penicillin, more than a century ago, has been one of the most significant advances in medicine. Despite the growing threat of antimicrobial resistance, which has rendered many other antibiotics ineffective, penicillin derivatives remain among the most widely prescribed antibiotics. Penicillin is biosynthesised by a large nonribosomal peptide synthetase (NRPS) enzyme, which assembles a tripeptide precursor ACV.
Author Correction: A PP1–PP2A phosphatase relay controls mitotic progression
Correction to: Nature https://doi.org/10.1038/nature14019 Published online 10 December 2014 In the version of this article initially published, there was an inadvertent error in the anti-HA blots in panel c of Extended Data Fig. 7 as it was a duplication of the blot in panel e. The phosphatase assay and HA control blots in panel c have therefore been replaced with data from another iteration of the same experiment.
Honoring Mary K. Chelton, Scholar, Reader, and Book Advocate
Dr. Mary K. Chelton, a retired professor in the Graduate School of Library and Information Studies at CUNY Queens College, passed away on August 28 at her home in Patchogue, NY. Chelton was a champion of books, authors, readers, libraries, and our profession. In 1978, she cofounded Voice of Youth Advocates (VOYA), a platform to support those working with young adults and help them navigate the burgeoning number of authors, titles, challenges, and opportunities for serving these readers.
Stromal lipid species dictate melanoma metastasis and tropism
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Keywords melanoma oxidative stress tropism metastasis aging melanoma metastasis OXPHOS liver tropism lipid metabolism aged skin Introduction Malignant melanoma primarily follows two metastatic routes from the skin: via lymphatics to the lymph nodes and distant organs or by direct hematogenous spread to distant sites,1 where visceral disease is responsible for death.
By Shilpa Gurung, Timothy Budden, Karthik Mallela, Benjamin Jenkins, Alex von Kriegsheim, Esperanza Manrique, David Millán-Esteban, Isabel Romero-Camarero, Fabio G. Amaral, Sarah Craig, Pedro Durao, Joanna Pozniak, Laura Stennett, Duncan Smith, Garry Ashton, Alex Baker, Kang Zeng, Gilbert O. Fruhwirth, Victoria Sanz-Moreno, Jair G. Marques, Albert Koulman, Jean-Christophe Marine, Tim C.P. Somervaille, Luisa Motta, Caroline Gaudy-Marqueste, Eduardo Nagore, Amaya Viros
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Cell Press
Verified
The assessment and management of acute dyspnoea: a case study
History Received 26 November 2024 Accepted 3 March 2025 Published online 7 April 2025 Published in print 3 April 2025
The assessment and management of acute dyspnoea
Barber CM, Cullinan P, Feary J British thoracic society clinical statement on occupational asthma. Thorax. 2022; 77:(5)433-442 https://doi.org/10.1136/thoraxjnl-2021-218597 Berliner D, Schneider N, Welte T, Bauersachs J The differential diagnosis of dyspnea. Dtsch Arztebl Int. 2016; 113:(49)834-845 Bickley SL, Szilagyi PG, Hoffman RM, Soriano RP Bates' guide to physical examination and history taking, 13th edn.
Think Generational Marketing Is the Lone Game in Town? Think Again
Audience segmentation based on values and behaviors, not age, drives deeper customer loyalty and higher ROI. It's time to rethink your marketing approach. Generational marketing's flaws. Generational segmentation often oversimplifies consumer behavior and leads to misguided strategies. Smarter segmentation strategies. Focusing on values, behaviors and needs over birth year results in more effective marketing. Real-world success stories.
The Scope of Nurses' Assessment of Deteriorating Patients in Coronary Care Units: A Mixed Methods Study
What does this paper contribute to the wider global clinical community? ○ Reports the number and type of clinical cues registered nurses working in coronary care units collect and how these inform their clinical impressions.Identifies the need for further research to deepen understanding of how registered nurses working in higher acuity areas use assessment frameworks and clinical reasoning models in their practice.
AI Tools for Marketing Drive Efficiency and Creativity
We must ensure our teams understand that AI is not a threat to their jobs but rather a powerful ally that can elevate their work to new heights. The Gist AI in agencies. AI tools are enhancing agency operations by automating tasks like data analysis and content optimization and allowing teams to focus on creativity and strategy. Human-AI collaboration. Instead of replacing talent, AI tools for marketing empower creative professionals and allow them to focus on strategic, high-value work.
AI Tools for Marketing Drive Efficiency and Creativity
We must ensure our teams understand that AI is not a threat to their jobs but rather a powerful ally that can elevate their work to new heights. AI in agencies. AI tools are enhancing agency operations by automating tasks like data analysis and content optimization and allowing teams to focus on creativity and strategy. Human-AI collaboration. Instead of replacing talent, AI tools for marketing empower creative professionals and allow them to focus on strategic, high-value work.
Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters
Keywords RNA Pol III RNA Pol II transcriptome gene regulation La chaperone nc96 nc111 nc143 tRNA RPPH1 Get full text access Log in, subscribe or purchase for full access. References 1. Sentenac, A. Eukaryotic RNA polymerases CRC Crit. Rev. Biochem. 1985; 18:31-90 2. Turowski, T.W. ∙ Boguta, M. Specific features of RNA polymerases I and III: structure and assembly Front. Mol. Biosci. 2021; 8, 680090 3.
UK: Labour ministers urged to impose stricter regulations on gambling advertising
Labour ministers are facing growing pressure from campaigners, politicians, and football figures to impose stricter regulations on gambling advertising, particularly in sports, to protect vulnerable groups, including children. At a Westminster summit, former Conservative leader Iain Duncan Smith, alongside other campaigners, urged the culture secretary, Lisa Nandy, to introduce tighter controls on gambling marketing.
Customer Experience
Just because we can, doesn’t mean we should. Shift focus now. Instead of relying on hyper-personalization, focus on creating tailored customer experiences that respond intelligently and empathetically to real-time customer behavior. Leverage reactivity. Reactivity in marketing often outperforms proactive approaches by allowing brands to adapt to customer needs and behaviors in real time, creating more genuine connections. Use smart tech.
The Contribution of Legionella anisa to Legionella Contamination of Water in the Built Environment
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Contribution of Legionella anisa to Legionella Contamination of Water in the Built Environment
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 4 July 2024 / Approved: 4 July 2024 / Online: 4 July 2024 (15:19:12 CEST) Crook, B.; Young, C.; Ridout, C.; Smith, D. The Contribution of Legionella anisa to Legionella Contamination of Water in the Built Environment. Preprints 2024, 2024070463. https://doi.org/10.20944/preprints202407.0463.v1 Crook, B.; Young, C.; Ridout, C.; Smith, D.
Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency - Nature Communications
Abstract BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we provide evidence that BRCA2 acts as a critical suppressor of head-on transcription-replication conflicts (HO-TRCs).
Breaking Through the Noise
The biggest challenge facing today's marketers isn't a lack of creativity – it's a lack of resources and time to be curious. Embrace curiosity. Marketers must prioritize curiosity over data overload to develop impactful, cohesive strategies. Authentic engagement crucial. Genuine connection with consumer interests leads to more effective audience retention. Curious lately? A lack of resources and time to be curious is holding marketers back.
Relevance Will Get You Further Than Attention Alone
While other MediaPost newsletters and articles remain free to all ... our new Research Intelligencer service is reserved for paid subscribers ... Subscribe today to gain access to every Research Intelligencer article we publish as well as the exclusive daily newsletter, full access to The MediaPost Cases, first-look research and daily insights from Joe Mandese, Editor in Chief. Become a subscriber today! If you're already a paid subscriber, please sign-in. Username Password Forgot?
Greater ecophysiological stress tolerance in the core environment than in extreme environments of wild chickpea (Cicer reticulatum) - Scientific Reports
Abstract Global climate change and land use change underlie a need to develop new crop breeding strategies, and crop wild relatives (CWR) have become an important potential source of new genetic material to improve breeding efforts. Many recent approaches assume adaptive trait variation increases towards the relative environmental extremes of a species range, potentially missing valuable trait variation in more moderate or typical climates.
hidden europe 50
Editorial hidden europe 50 Welcome to hidden europe 50. We live and work in a city where foreign nationals make an immense contribution to the local economy, to society and to the arts. Berlin is in that respect very typical of many places in Europe. In hidden europe, we ... Only Fit For Wild Ducks Catch the spirit of Scotland’s Outer Hebrides with Gaelic psalm singing at a country church in Lewis or Marian devotions on the Isle of Eriskay.
hidden europe 55
Editorial hidden europe 55 We take time out in hidden europe 55 to sample Switzerland’s excellent white wines made from the Chasselas grape, visit the Ukrainian city of Lviv and the Abkhaz-Georgian borderlands and explore the art of falconry in Lower Austria. We ... The Art of Falconry Falconry has invariably been associated with a measure of privilege and wealth. So it's no surprise that the French Revolution led to a downturn in falconry.
Ecophysiological adaptations shape distributions of closely related trees along a climatic moisture gradient - Nature Communications
Abstract Tradeoffs between the energetic benefits and costs of traits can shape species and trait distributions along environmental gradients. Here we test predictions based on such tradeoffs using survival, growth, and 50 photosynthetic, hydraulic, and allocational traits of ten Eucalyptus species grown in four common gardens along an 8-fold gradient in precipitation/pan evaporation (P/Ep) in Victoria, Australia.
‘Ok’ To ‘Amazed’ – Tapping Into The Psychology Of Personalisation To Make Brand Related Experiences Unforgettable - Retail News And Events
The evolution of shopping habits and consumer behaviours over the past decade are well documented, especially for younger generations. What continues to emerge is how the seismic changes of the last few years, combined with technological advances and a shift in consumer attitudes towards brands, have created unique challenges for brand owners, retailers and their marketing service providers. There is huge pressure on marketers to focus on business outcomes and demonstrable ROI.
A Dream of Fecunda (part two)
Editor’s Note: Below is an extract from the book, The Vast and the Spurious: 25 Problems for Feminism. _________________________ Part Two – Rape Culture and Guilt Part one of this article was about a fictional all-women country called Fecunda. Part two looks at a more serious question – are men as a class responsible for individual crimes against women, and are women entitled to hate them? It is after such crimes in my country, Australia, that feminist anger against men reaches a peak.
A Dream of Fecunda (part one)
Editor’s Note: Below is an extract from the book, The Vast and the Spurious: 25 Problems for Feminism, by Duncan Smith. In this excerpt he examines the feminist vision of creating a utopia peopled only by women. _____________________________ How long have we had feminism? It seems like eternity but it’s only about fifty years since it really fired up. In those fifty years, there have been thousands of books, talks, and courses on the subject, but we’re still no closer to gender Utopia.
From brain waves to brand success: How neuroscience can elevate your marketing
18 August 2023 Neuromarketing uses neuroscience and psychology to better understand consumer behaviour and develop more effective marketing strategies. This includes techniques like monitoring brain activity, eye tracking and skin response to measure emotional reactions to marketing messages. This piece explores how brands can use these insights to create more effective marketing campaigns.
The Reading Life
A phrase I often use is “the reading life.” Someone recently asked me exactly what I meant by it. On the surface, defining the reading life seems like it should be straightforward. It gets complicated, however, by the word “reading.” The American Heritage (my dictionary of choice) lists seven definitions for the word “reading.” The word “read” is even more challenging. We depend on the word’s context to determine the right choice.
Eurolabel Embraces GEW ArcLED Technology in Transition to UV LED
By Duncan Smith, GEW, Corporate Communications Elisabetta Brambilla and her husband Aldo Franco, respectively President and Vice President of Eurolabel. Eurolabel is an established company in the self-adhesive label market in Italy. Founded in Milan in 1964, it began as a family business and has grown to become a thriving company with almost 80 employees and an annual turnover of around €12 million.
The Central Station
By Olga Tokarczuk Olga Tokarczuk is young for a Nobel Prize winner. She received the award four years ago, at fifty-seven, for “a narrative imagination that with encyclopedic passion represents the crossing of boundaries as a form of life.” Her painstakingly researched novels recover forgotten chapters of Eastern and Central Europe’s multilingual, multicultural history, drawing on Gnosticism, Kabbalah, Apocrypha, tarot, and pre-Christian paganism.
Hamlyn Symposium 2023
Sagentia Innovation is excited to be sponsoring the Hamlyn Symposium taking place June 26-29, 2023. Tim Frearson, Head of Electronics and Systems, alongside THINK Surgical will be hosting a session on June 27 at 1pm discussing the development of the TMINI Robotic System. TMINI system is an exciting step forward in miniature robotics for Orthopaedics.
Waking Up to Woke
Duncan Smith writes on his website that we are living in turbulent times, which is bad for society but good for a novelist because conflict is the key to drama. That is not all that a good novel needs, though.
Case Study: etic.a Switches Entire Operation to UV LED Curing
By Duncan Smith, GEW, Corporate Communications GEW’s latest customer case study video looks at a highly successful label printing company in Pomezia, on the outskirts of Rome. etic.a was founded in 2009 by Gianni Olivieri and his wife Patrizia. The company has grown steadily and now employs around 35 people, generating a revenue of around 10 million euros.
Episode 117: Bumper Bookmail for Book Week
Bumper Bookmail for Book Week This week, we’re all about the brand-new books, celebrating the joy of CBCA Book Week with a bumper bookmail episode. Plus, Allison has tips for authors prepping for a book launch and Megan suggests heading outdoors. Books we mention Click on the links to buy from Booktopia and support the podcast production. Sign up here for the Your Kid’s Next Read newsletter and your chance to win our #bookmail. ‘River to Bay: Victoria’s Maritime History’ by Carole Wilkinson.
hidden europe 68
In this new issue of the magazine we present articles with a focus on Sweden, France, Greece, Spain and Malta. We have a number of thematic pieces too, taking inspiration in part from rail travel which is experiencing such a welcome renaissance in ... Thiérache is one of those unsung regions of northern France through which travellers often pass but too few stop to explore. Guest contributor Rudolf Abraham makes time to discover the rolling hills, gentle valleys and fortified churches of ...
Read, Share and Shape the News
Poll: When was the last time you sent a hand-written letter or card? YESTERDAY, AN POST launched a new digital stamp. The stamp is now available to buy through the An Post App and will cost €2 for regular envelopes. Users get instant access to a unique 12-digit code through the An Post App, which customers can then handwrite onto their envelope or postcard where a traditional stamp would go. This morning we want to know: When was the last time you sent a hand-written letter or card?
Opinion: Care and community workers fill the gaps left by the State - they need a pay rise
THEY PROVIDE SOME of our most essential frontline services, caring for the vulnerable and maintaining our communities. Despite this, tens of thousands of workers employed in community, voluntary, and section 39 organisations are in a dire situation. Squeezed by the runaway cost of living crisis and stuck on the same rate of pay since 2008, they have no way of securing a pay rise – apart from taking strike action. Labour supports their actions.
Is this really the best-ever Penrith team?
According to James Fisher-Harris, he is playing in the best-ever Penrith team. “Everyone gone before us, much respect. But as I said last night – we are the greatest Penrith team ever,” the two-time premiership prop said. In saying this, James may have fallen prey to two serious factors.
GE agrees to EIB 'exclusion' for legacy Alstom Slovenia conduct
The European Investment Bank and GE Steam Power have reached an agreement regarding historical cases of prohibited conduct by various Alstom Steam Power companies, in particular, Alstom Power Systems S.A (France), Alstom Power Systems GmbH (Germany), and Alstom Hrvatska d.o.o (Croatia) in the Šoštanj Power Project in Slovenia.
Bally's Black Hawk Casino Set To Host 2022 Mid-States Poker Tour
The 2022 Mid-States Poker Tour circuit continues through the summer as a great alternative if you’re not in Las Vegas at the World Series of Poker. The next stop on the schedule is Bally’s Black Hawk Casino, in Black Hawk. Starting on July 6th and running through July 17th, Bally’s Black Hawk will host an extensive tournament series culminating with a $300,000 guaranteed main event. This event begins on July 14th and has three starting flights. The main event will have a $1,100 entry fee.
Only in Seville - all you need to discover this amazing city
3 min read by Matilda Hickson The Only In guide books are a joy to anyone who is interested in discovering unique locations, hidden corners and unusual objects that make up the history of a city. Based on a bend in the Guadalquivir River, Seville has long been coveted as a staging post and has seen numerous visitors. From the Poenicians in the 8th century, the Romans and Visigoths to the Abbadids, Almoravids and the Almohads (who made Seville their European capital), they have all left their mark.
Integrity at Work: on minimizing corruption in international organizations
I am delighted Duncan Smith[1] responded positively to my request to write a Guest Briefing for Oxford House. The Briefing is a taster of his treatment of an important theme. Christopher Hancock (Director) Frauds and tricksters are common in fiction. From the Wizard of Oz to The Talented Mr Ripley fictional characters have portrayed the alluring arts of deceit and corruption.
Development and psychometric evaluation of the Attitudes Towards Recognising Early and Noticeable Deterioration (ATREND) scale
3.1.2 Stage 2: Content and face validation Following item generation, a panel of 15 content experts evaluated the content validity of these 34 items. The content experts comprised nurse practitioners, nurse educators and nurse researchers from Australia (n = 3), the Netherlands (n = 2), New Zealand (n = 1), Singapore (n = 7) and the United Kingdom (n = 2).
Collaborative practice among general ward staff on escalating care in clinical deterioration: A systematic review
Synthesis Given the heterogeneity of the study designs, a narrative synthesis approach was undertaken to summarise and report the finding. Following the data-based convergent qualitative synthesis approach, quantitative data from each study were converted into a textual summary (Pluye & Hong, 2014).
Episode 44: Literary Awards Season
In episode 44 of the Your Kid’s Next Read podcast: Literary Awards Season It’s that time of year, when there seems to be a new literary longlist or shortlist every week. But how are literary awards judged and what do they mean for teachers, parents and authors? Megan and Allison take a look behind the scenes at Australian children’s literary awards. Plus, why a demonstration of vocabulary doesn’t make a great story and why you should encourage your kid to hang out in the library.
Evidence Suggests Biden And Kamala Committed Campaign Finance Fraud... This Is BIG
VOTER FRAUD? HOW ABOUT CAMPAIGN FINANCE FRAUD? JOE BIDEN AND KAMALA HARRIS AIDED BY ‘DARK MONEY’ DEMS USED TO HATE By Duncan Smith (TNS) Do Democrats really stand for anything anymore except power? Don’t worry about answering that; it was a rhetorical question. ADVERTISEMENT - STORY CONTINUES BELOW Of course, they don’t. take our poll - story continues below Whom do you consider to be the most corrupt Democrat Politician?
Engaging Readers
Readers’ Advisory + Reader Engagement = Reader Services for Our Times Autumn Friedli felt she could be getting more out of her interactions with readers but couldn’t quite put her finger on what was missing. Megan Johnson’s older reader (whom she had worked with for 14 years!) had favorite authors who weren’t writing fast enough, and the reader wasn’t willing to try anything new.
Sandviper TOC All-Star Game Thursday
For nearly two decades, Wesley Frater has set standards with a post season all-star football game that has hosted some of the top players and coaches in south Florida. Originally known as the Miami-Dade County All-Star Game, this was an event that everyone wanted to be a part of. "We have enjoyed 23 years of success with athletes from Dade and Broward participating,” said Frater, game founder and director.
Senior Year - Duncan Smith
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