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Dunming Zhu

As seen in: Nature, Wiley Online Library
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Articles

Catalytic Promiscuity and Cascade Reaction Mechanism of Ketosteroid Isomerases for Addition Reactions of Cyclic Enones

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By Xuemei Li, Mengsha Li, Yangyang Chen, Weidong Liu, Yiyin Liu, Rui Zhang, Xiang Sheng, Jinhui Feng, Qiaqing Wu, Dunming Zhu, Chuanfang Wu, Jinku Bao
| Nature Verified
Abstract Steroidal medicines are a vital class of pharmaceuticals, with their active ingredients primarily derived from natural steroids. A key step in their biosynthesis involves the isomerization of ∆5−3-ketosteroids to ∆4−3-ketosteroids, catalyzed by ketosteroid isomerase (KSI). In this study, we discover that KSI exhibits an unexpected catalytic promiscuity, efficiently converting cyclic enones into homo- and hetero-addition products.
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Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals

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By Jinhui Feng, Qiaqing Wu, Dunming Zhu, Yanhe Ma
| Wiley Online Library Verified
Review Prof. Jinhui Feng, Prof. Jinhui Feng orcid.org/0000-0001-9320-7323 National Technology Innovation Center of Synthetic Biology, National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin Airport Economic Area, 32 Xi Qi Dao, Tianjin, 300308 P. R. China Search for more papers by this author Prof. Qiaqing Wu, Prof.
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