Yiyin Liu

Abstract Steroidal medicines are a vital class of pharmaceuticals, with their active ingredients primarily derived from natural steroids. A key step in their biosynthesis involves the isomerization of ∆5−3-ketosteroids to ∆4−3-ketosteroids, catalyzed by ketosteroid isomerase (KSI). In this study, we discover that KSI exhibits an unexpected catalytic promiscuity, efficiently converting cyclic enones into homo- and hetero-addition products.

Communication Wen-Jing Xiao Corresponding Author E-mail address: wxiao@mail.ccnu.edu.cn E-mail address: wenjing_xiao@yahoo.com Central China Normal University, Chemistry, 152 Luoyu Road, 430079 Wuhan, CHINA Search for more papers by this author Abstract The transition‐metal‐catalyzed cyanations of aryl halides are among the most used methods for synthesizing aryl nitriles. Despite tremendous advances, cyanating an aryl halide in a facile and benign fashion has generally been unsuccessful.