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Durgadas Cherukaraveedu on Muck Rack

Durgadas Cherukaraveedu

As seen in: The Journal of Clinical Investigation
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Articles

Mononuclear phagocyte–specific cGAS/STING targeting suppresses experimental choroidal neovascularization

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By JCI Insight, Le Shi, Durgadas Cherukaraveedu
| The Journal of Clinical Investigation
Abstract Neovascular age-related macular degeneration (nAMD) is a major cause of blindness and is characterized by pathologic angiogenesis, specifically choroidal neovascularization (CNV). Mononuclear phagocytes (MPs), including infiltrating systemic monocyte-derived macrophages and retinal microglia, play critical roles in promoting CNV. The cGAS/STING pathway is increasingly implicated in multiple neuronal and systemic diseases and recently in ocular neovascularization.
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