Dylan Barbera

By Matthew Fosbrink, Megan Zais, Dylan Barbera, and Jonathan Shaffer Ensuring viral safety remains a critical requirement in biopharmaceutical development, particularly as products grow more complex and timelines continue to compress. This application note explores a modern, molecular approach to adventitious virus detection using hybrid capture–based targeted sequencing aligned with ICH MAP, RAP, and HAP testing expectations.

By Matthew Fosbrink, Megan Zais, Dylan Barbera, and Jonathan Shaffer Ensuring viral safety remains a critical requirement in biopharmaceutical development, particularly as products grow more complex and timelines continue to compress. This application note explores a modern, molecular approach to adventitious virus detection using hybrid capture–based targeted sequencing aligned with ICH MAP, RAP, and HAP testing expectations.

Highlights • Plaids drive both suppression and facilitation in populations of mouse V1 neurons • Functional inactivation of cortex does not alter modulation by mask gratings • The effects of the mask grating depend on stimulus phase in weakly tuned neurons • The geometry of feedforward inputs defines cross-orientation interactions Summary Sensory neurons are modulated by context.