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Edahí González-Avalos on Muck Rack

Edahí González-Avalos

As seen in: Nature, Genome Biology
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Articles

BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells - Nature Immunology

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By Hyungseok Seo, Edahí González-Avalos, Wade Zhang, Payal Ramchandani
| Nature Verified
Abstract The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence of AP-1 imposes a negative feedback program of T cell hyporesponsiveness (exhaustion). Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor models.
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Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

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By Atsushi Onodera, Edahí González-Avalos, Chan-Wang Jerry Lio, Romain O. Georges
| Genome Biology Verified
Atsushi Onodera ORCID: orcid.org/0000-0002-3715-94081,2,3, ORCID: orcid.org/0000-0002-6817-48541,4, Chan-Wang Jerry Lio ORCID: orcid.org/0000-0003-3876-67411,5, Romain O.
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