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Late Hepatic Toxicity Surveillance for Survivors of Childhood, Adolescent and Young Adult Cancer: Recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Highlights • Cancer survivors are at risk for chronic liver disease, especially those treated with radiotherapy to the liver. • This guideline provides recommendations for the surveillance of late hepatotoxicity. • Physical examination and measurement of serum liver enzyme concentrations once at entry into long-term follow-up is recommended for at-risk survivors. Abstract Background Survivors of childhood, adolescent and young adult (CAYA) cancer may develop treatment-induced chronic liver disease.
European PanCareFollowUp Recommendations for surveillance of late effects of childhood, adolescent, and young adult cancer
Highlights • Long-term follow-up care is important for survivors of childhood cancer. • Evidence-based guidelines to direct care are essential, but lacking for many topics. • We developed harmonised surveillance recommendations to bridge the gap. • Survivor representatives were involved in the formulation of recommendations. Abstract Background Long-term follow-up (LTFU) care for childhood, adolescent, and young adult (CAYA) cancer survivors is essential to preserve health and quality of life (QoL).
Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia
1. Bhakta N Liu Q Ness KK et al. The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE). Lancet. 2017; 390: 2569-2582 2. Robison LL Hudson MM Survivors of childhood and adolescent cancer: life-long risks and responsibilities. Nat Rev Cancer. 2014; 14: 61-70 3. Pui CH Yang JJ Hunger SP et al. Childhood acute lymphoblastic leukemia: progress through collaboration. J Clin Oncol. 2015; 33: 2938-2948 4. Toft N Birgens H Abrahamsson J et al.
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