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Edward O’Brien on Muck Rack

Edward O’Brien

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Articles

HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA

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By Alfred M. Lentzsch, Ziyi Fan, Inayat U. Irshad, Edward O’Brien, Ajeet Sharma, Shu-ou Shan
| Cell Press Verified
Keywords N-acetyltransferase HYPK ribosome cotranslational protein modification exchange factor Introduction The ribosome is a macromolecular machine that synthesizes the proteome of all living organisms.
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Noncovalent Lasso Entanglements are Common in Experimentally Derived Intrinsically Disordered Protein Ensembles and Strongly Influenced by Protein Length and Charge Original

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By Quyen Vu, Ian Sitarik, Mai Li, Edward O’Brien
| ACS Publications
Introduction Click to copy section linkSection link copied! Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are widespread in all organisms (1,2) and play crucial roles in various biological processes, including signal transduction, (3−5) molecular recognition, (6−9) and phase separation. (10,11) Unlike structured proteins and domains, IDPs/IDRs do not adopt a single, well-defined three-dimensional structure.
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Protein misfolding involving entanglements providesa structural explanation for the origin of stretched-exponential refolding kinetics

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By Dadong Liu, Katja Mauelshagen, Suman Karan, Yang Jiang, Stephen Fried, Edward O’Brien, Yingzi Xia, Ian Sitarik
| Science Magazine Verified
Abstract Stretched-exponential protein refolding kinetics, first observed decades ago, were attributed to a nonnative ensemble of structures with parallel, non-interconverting folding pathways. However, the structural origin of the large energy barriers preventing interconversion between these folding pathways is unknown. Here, we combine simulations with limited proteolysis (LiP) and cross-linking (XL) mass spectrometry (MS) to study the protein phosphoglycerate kinase (PGK).
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