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Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

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By Mollie K Huber, Adrienne E Widener, Alexandra E Cuaycal, Dylan Smurlick, Elizabeth Butterworth, Nataliya Lenchik, JING CHEN, Maria Beery, Helmut Hiller, Irina Kusmartseva, Marjan Slak Rupnik, Martha Campbell-Thompson, Mark Atkinson Verified, Clayton E. Mathews, Edward Phelps, Ellen Verney, Ivan C. Gerling
| Cell Reports Verified
Results A period of beta cell dysfunction during T1D development has been well established in clinical studies.7,8,10,11,12,13,14 However, this dysfunction has been understudied in isolated islets or live tissue; thus, the underlying mechanism(s) remain unclear. Islets are difficult to isolate from T1D donors due to the islet degradation that is associated with disease.31 Additionally, the isolation procedure results in islets being removed from their microenvironment and associated immune cells.
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