Edwige B. Garcin

1 INTRODUCTION Disulfide bonds have classically been shown to stabilize proteins by maintaining protein overall structure via intermolecular and intra-domain covalent bonds between two cysteine residues. These structural disulfide bonds are essential for the stability of secreted proteins destined for the harsh oxidizing extracellular environment, but also in the regulation of proteins function.

Restoration of Fork Protection to BRCA1-Deficient U2OS Cells Does Not Cause PARP Inhibitor Resistance Overexpression of RADX Causes Nascent Strand Degradation that Is Rescued by Inhibition of MRE11 or ZRANB3 Differential Requirements of RAD51 in Fork Reversal and Protection RADX Outcompetes RAD51 for ssDNA but Is Expressed at Lower Levels Our data indicate that loss of RADX mimics RAD51 overexpression and confers fork protection to cells lacking BRCA1/2, FANCA, FANCD2, or BOD1L—all situations...