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Edziu Franczak on Muck Rack

Edziu Franczak

As seen in: Nature, Science Magazine, BioRxiv
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Articles

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart

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By Feng Jiang, Antoine Diez, Juncheng Yao, Kelsey H. Fisher-Wellman, Richard D Lutze, Logan Kirkland, Ju Youn Beak, Mansi Goyal, Raghu Nagalingam, Samantha Morrissey, Peyton B. Sandroni, Wei Huang, Julian D. Bailon, Melissa A. Schroder, Lars Albrecht, Ethelyn Ofei, Andrew Chin, Thomas Green, Joseph McClung, McLane Montgomery, James Hagen, Brett Chrest, Edziu Franczak, Raphael T. Aruleba, Polina Krassovkaia
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Trametinib (Trm) is a highly selective mitogen-activated protein kinase kinase (MEK) inhibitor that potently and persistently abrogates extracellular signal–regulated kinase 1/2 activation.
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Chemical-induced colitis lowers mitochondrial bioenergetic function in colonic tissue with minimal impacts on the proteome

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By McLane Montgomery, Raphael T. Aruleba, Polina M. Krassovskaia, Emely A. Pacheco, Edziu Franczak, Brett Chrest, Thomas Green, Tonya N. Zeczycki, Kelsey H. Fisher-Wellman, Masara A. Al Obaidi, Joeseph M. McClung
| Nature Verified
Abstract Dextran sulfate sodium (DSS) is widely used to chemically-induce both colitis and colorectal cancer when administered alongside azoxymethane (AOM). DSS functions by disrupting the colonic epithelial barrier, triggering widespread inflammation within the colon. While DSS is a valuable tool for studying colitis-related diseases, its impact on mitochondrial bioenergetics and the proteomic landscape of colonic tissue remains poorly understood.
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Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.

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By Taylor J. Kelty, Edziu Franczak, Nicole Gay, Gina M. Many
| BioRxiv
Abstract The mechanisms by which exercise modulate liver metabolism, a central regulator of systemic metabolism, are poorly understood. Leveraging data from MoTrPAC, we analyzed liver adaptations across 1, 2, 4, and 8 weeks of exercise in male and female rats using multi-omic approaches.
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