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Ee Shan Liau on Muck Rack

Ee Shan Liau

As seen in: Nature, JoVE- Journal of Visualized Experiments
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Articles

The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation - Nature Communications

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By Ya-Ping Yen, Ee Shan Liau, Chuan-Che Wu, Fang-Yu Hsu, Wei Zhao, Jui-Hung Hung, Chuan He, Ting-Hsiang Lung, Guan-Lin Huang
| Nature Verified
Abstract Amyotrophic lateral sclerosis (ALS) is a swiftly progressive and fatal neurodegenerative ailment marked by the degenerative motor neurons (MNs). Why MNs are specifically susceptible in predominantly sporadic cases remains enigmatic. Here, we demonstrated N6-methyladenosine (m6A), an RNA modification catalyzed by the METTL3/METTL14 methyltransferase complex, as a pivotal contributor to ALS pathogenesis.
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Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons - Nature Communications

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By Ee Shan Liau, Suoqin Jin, Yen-Chung Chen, Qing Nie, Maëliss Calon, Stéphane Nedelec
| Nature Verified
Abstract Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate movements. In vertebrates, the molecular identities of the cardinal MN types such as those innervating limb versus trunk muscles are well elucidated. Yet the identities of finer subtypes within these cell populations that innervate individual muscle groups remain enigmatic. Here we investigate heterogeneity in mouse MNs using single-cell transcriptomics.
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Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy

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By Jun-An Chen, Ee Shan Liau, Ya-Ping Yen
| JoVE- Journal of Visualized Experiments
LSFM provides detailed 3D visualization of MN trajectory and axon arborization in mouse embryos. Under bright field, tissues appear completely transparent after being immersed in the commercial clearing reagent. No shrinkage or swelling of the sample was noticed after up to one week of storage in clearing reagent before imaging. Under fluorescence channel, motor neurons are labeled with transgenically expressed GFP (Movie 1). In some instance, details of the axon structure are compromised.
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