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Eleanor Barker

As seen in: Wiley Online Library, MDPI
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Articles

A Systematic Review and Meta-Analysis of Tourniquet Pressures in Upper Limb Surgery

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By Kayen Chan, Rawan Jaibaji, Eleanor Barker, Cyrus Talwar
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Functional analysis of epilepsy‐associated GABAA receptor mutations using Caenorhabditis elegans

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By Ami Gadhia, Eleanor Barker, Alan Morgan, Jeff W. Barclay
| Wiley Online Library Verified
GABAA receptor mutations are associated with genetic generalized epilepsy. Genetic deletion of the GABAA worm orthologue, unc-49, exhibits functional defects including an increase in seizure-like convulsions. The human GABAA receptor can partially functionally replace unc-49. Epilepsy-associated variants of GABAA have functional defects including an increase in seizure-like convulsions. C. elegans are an inexpensive in vivo model to investigate GABAA receptor mutations and epilepsy in general.
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