Antibiotic resistance has rendered many conventional antibiotics obsolete and contributed to the deaths of 1.2 million people in 2019. (1) The ESKAPE pathogens─Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.─pose the largest challenges as they contain multiple resistance mechanisms, surviving up to 10–1000-fold the normal doses of antibiotics.