1. Introduction Cerebral small vessel disease (CSVD), associated with age and vascular risk factors, is the main cause of vascular cognitive impairment, mixed variants of Alzheimer’s disease, and is a significant cause of stroke, disability, and mortality [1,2,3,4,5]. Arterial hypertension (AH) is the main risk factor for age-related CSVD [5,6,7]. However, a strategy to prevent dementia through standard and aggressive control of hypertension has shown inconsistent results [8,9,10].
