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Elena S. Barskaya on Muck Rack

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New Complexes of Copper (II) and Zoledronic Acid: Relevance to Oxidative Death of Leukemia Cells in the Bone Marrow

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By Kirill Chernov, Elena S. Barskaya, Artemii M. Savin, Albina S. Petrova
| Preprints.org
Submitted: 14 January 2026 You are already at the latest version Copper-organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the tumor site.
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