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Elif Sarinay Cenik on Muck Rack

Elif Sarinay Cenik

As seen in: Nature, PLOS Biology, Cell Press
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Articles

Maternal regulation of translation capacity across generations

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By Elif Sarinay Cenik
| PLOS Biology Verified
Ribosomes are among the most abundant macromolecular complexes in the cell, and in bacteria their abundance is tightly coupled to growth rate. Regulatory circuits couple nutrient availability to ribosome synthesis so that cells increase translational capacity when biosynthetic demand increases [1]. In multicellular animals, however, this relationship is embedded in a more complex physiological context.
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Is mitochondrial function at the heart of ribosome-related diseases?

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By Qiuxia Zhao, Elif Sarinay Cenik
| Cell Press Verified
Keywords ribosome biogenesis mitochondrial function ribosomopathies mitochondriopathies Get full text access Log in, subscribe or purchase for full access. References 1. Surya, A. ... Differential impacts of ribosomal protein haploinsufficiency on mitochondrial function J. Cell Biol. 2025; 224, e202404084 2. Cunningham, J.T. ... mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature. 2007; 450:736-740 3. Avolio, R. ...
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Functional and structural basis of extreme conservation in vertebrate 5′ untranslated regions

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By Elif Sarinay Cenik, Lihua Jiang, Hua Tang, Rhiju Das
| Nature Verified
Abstract The lack of knowledge about extreme conservation in genomes remains a major gap in our understanding of the evolution of gene regulation. Here, we reveal an unexpected role of extremely conserved 5′ untranslated regions (UTRs) in noncanonical translational regulation that is linked to the emergence of essential developmental features in vertebrate species.
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