Nonstandard Abbreviations and Acronyms CEC clinical end point committee CRNM clinically relevant nonmajor DOAC direct oral anticoagulant HDER higher‐dose edoxaban regimen ICH intracranial hemorrhage ISTH International Society on Thrombosis and Haemostasis LDER lower‐dose edoxaban regimen VKA vitamin K antagonist Clinical Perspective • Epistaxis is common among patients on anticoagulation for atrial fibrillation, occurring in nearly 1 in 20 patients.