Emilien L. Jamin

Pollution represents a silent global public health crisis, contributing to an estimated 9 million premature deaths annually1. It is likely that this figure underestimates the true burden, as only a fraction of the thousands of chemicals in global commerce have been adequately tested for safety or measured in humans, either individually or even more rarely as mixtures.

CONFLICT OF INTEREST STATEMENT C. Jacques, A. Noustens, C. Lauze, G. Doat, S Bessou-Touya, and H. Duplan were employees of Pierre Fabre group (France) during the conduct of the study and the result analyses. E.L. Jamin, I. Jouanin, and L. Debrauwer were employees of INRAE during the conduct of the study and the result analyses. E.

The secondary metabolome of Penicillium nordicum is poorly documented despite its frequent detection on contaminated food and its capacity to produce toxic metabolites such as ochratoxin A. To characterize metabolites produced by this fungi, we combined a full stable isotopes labeling with the dereplication of tandem mass spectrometry (MS/MS) data by molecular networking. First, the untargeted metabolomic analysis by high-resolution mass spectrometry of a double stable isotope labeling of P.