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Emilio JA Roldán

As seen in: Nature
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Articles

Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures

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By Jinsen Lu, Srinivasa Rao, Helen Knowles, Haoqun Zhan, Beatriz Gámez, Mingyu Qin, Eleanor Platt, Lucy Frost Verified, Tiffany-Jayne Allen, Gayle Marshall, Kilian V. M. Huber, Ludwig G. Bauer, Iolanda Vendrell, Darragh O’Brien, Benedikt M. Kessler, Anne Horne, Ian R Reid, Chas Bountra, James Kirkland, Sundeep Khosla, Frank H. Ebetino, Emilio JA Roldán, R. Russell, James Edwards
| Nature Verified
Abstract Bisphosphonates (BPs) have been used effectively to treat excessive bone loss for over 50 years. Recent clinical evidence suggests extra-skeletal benefits but how this occurs remains unknown. Here we use a panel of human, murine and cellular assessments to chart BP-induced ageing-related changes both systemically and at local organ sites.
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First in - Silico Study of Two Echinococcus granulosus Glyceraldehyde-3-Phosphate Dehydrogenase Isoenzymes Recognized by Liver Cystic Echinococcosis Human Sera[v1] | Preprints.org

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By Facundo Ariel Agüero, Andrea Maglioco, María Pia Valacco, Emilio JA Roldán
| preprints.org
Submitted: 12 September 2025 Posted: 15 September 2025 You are already at the latest version Cystic echinococcosis (CE) is an endemic zoonotic disease caused by Echinococcus granulosus, which forms cysts in ungulates’ intermediate hosts. Humans are accidental hosts, and CE affects more than one million people worldwide. Imaging remains the diagnostic gold standard, outperforming serological methods.
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