Emma Claire Lones

Highlights • The N-terminal domain of Sen1 mediates replisome association • Ctf4 and Mrc1 bind to Sen1 and promote its recruitment to the replisome • The sen1-3 allele abrogates replisome binding, but not transcription termination • sen1-3 cells are sensitive to high levels of R-loops and defects of S phase checkpoint Summary DNA replication and RNA transcription compete for the same substrate during S phase. Cells have evolved several mechanisms to minimize such conflicts.

AE adverse event ALU arterial leg ulcer CINAHL cumulative index to nursing and allied health literature CMC carboxymethylcellulose CRD centre for reviews and dissemination DFU diabetic foot ulcer ECM extracellular matrix EUnetHTA European Network for Health Technology Assessment HAS Haute Autorité de Santé HTA health technology assessment MMP matrix metalloproteinase NFLU non-contact low frequency ultrasound NHS national Health Service NICE National Institute for Health and Care Excellence...