Emmry Stimson on Muck Rack

Emmry Stimson

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Articles

Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents

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By Qian Guo, Chan Wang, Vincent Mauduit, Alexey Stukalov, Maede Mohebnasab, Alex Sagar, Simon Williams Verified, Berk Maden, Tal Eitan, Krista Barone, Jennifer D. Motter, Alexa K. Dowdell, Fred Robinson, Cyrille Guillot-Tantay, Justin Little, Kleio-Maria Verrou, Ángel Gálvez-Merchán, Peng Guo, Hui Gao, Austin G. Holmes, Alexandra Bartlett, Dong Xin, Hannah Futeran, Serafim Batzoglou, Shreyas Joshi, Mercy Rophina, Francesca Zanoni, Mohamed A. Elzawahry, John Fallon Verified, Syed Abbas, Kim M. Olthoff, Charles S. Abrams, Sagar Chhangawala, Adam D. Griesemer, Peter J Friend, Asim Rais Siddiqui, Eloi Schmauch, Brian D. Piening, Abraham Shaked, Brendan J. Keating, Susanna Vikman, Zasha Zayas, Kiana Moi, Emmry Stimson, Diana Argibay, Leah Wu
| Nature Verified
Abstract Extracorporeal liver cross-circulation (ELC) using gene-edited porcine liver xenografts offers a potential bridge therapy for liver failure. We previously performed five ELC procedures in four brain-dead human decedents, during which the recipients developed severe thrombocytopenia. The porcine liver xenografts maintained their parenchymal structure, with immune cell infiltration and detectable IgM deposition on endothelial cells.
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