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Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents
Abstract Extracorporeal liver cross-circulation (ELC) using gene-edited porcine liver xenografts offers a potential bridge therapy for liver failure. We previously performed five ELC procedures in four brain-dead human decedents, during which the recipients developed severe thrombocytopenia. The porcine liver xenografts maintained their parenchymal structure, with immune cell infiltration and detectable IgM deposition on endothelial cells.
Bacillus Calmette–Guérin (BCG) immunotherapy reprograms CNS immunity and alters Alzheimer’s biomarkers: results from two open-label clinical trials
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Abstract Immune aging may contribute to Alzheimer’s disease. Bacillus Calmette–Guérin (BCG), a vaccine known to induce trained immunity, has been linked to reduced Alzheimer’s risk in prior studies. However, whether trained immunity can be observed in the human central nervous system remains unclear. We assessed whether BCG induces trained immunity–like responses in adults with and without Alzheimer’s-related changes.
By Marc Weinberg Verified, Mahesh Chandra Kodali, Zhaozhi Li, Arianna R. Tidball, William Reynolds, Hadia Fatima, Pia Kivisäkk, Arpita Kulkarni, Alexandra Bartlett, Shannan Ho Sui, Willem M. Kühtreiber, Alison McManus, Rudolph E. Tanzi, Sudeshna Das, Denise L. Faustman, Steven Arnold, Jake A. Galler, Cathrine Young, Kelli Devitte- McKee, Mandovi Chatterjee, James M. Billingsly
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Nature
Verified
Kennedys recognised in the 2027 edition of Best Lawyers Australia and Singapore
Kennedys is pleased to have been recognised in the 2027 edition of Best Lawyers in Australia and Singapore.
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Alexandra
Contact Alexandra, search articles and posts on X, monitor coverage, and track replies from one place.
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