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Enrique I. Kuper

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Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial

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By Baltazar Gomez-Mancilla, Kenneth M Dürsteler, Marc Vogel, Marcus Herdener, Marta Torrens, Antoni Gual, Ricardo Corral, Bartolomé P. Gálvez, Enrique I. Kuper, Daniel L. Mosca, Swati Dumitras, Nicole Pezous, Maria Berkheimer, Ela Walker, Fabrizio Gaspar
| Science Magazine Verified
Editor’s summary Cocaine use disorder is associated with dysregulated glutamate neurotransmission. Preclinical studies have indicated that modulation of glutamate signaling by antagonizing metabotropic glutamate receptor 5 (mGluR5) can attenuate cocaine use in animal models. Gomez-Mancilla et al. conducted a randomized, placebo-controlled phase 2 clinical trial of mavoglurant, a selective noncompetitive antagonist of mGluR5, in 68 patients with chronic cocaine use disorder who also used alcohol.
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