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Epfl Sv Isrec

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Articles

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL Original

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By Epfl Sv Isrec, Ruiz Buendía, Colin E.J
| Ash Publications
Skip Nav Destination Research Article| January 12, 2022
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Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

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By Elizabeth Allen, Epfl Sv Isrec, Pascal Miéville, Carmen M. Warren, Sadegh Saghafinia
| Cell Press Verified
AI Treatment of Mouse PanNETs Produces Upregulation of Glucose and Lactate Transporters in Patterns Suggestive of Metabolic Symbiosis Mouse PanNET Tumors and Cell Lines Consume and Catabolize Lactate to Establish Metabolic Symbiosis mTOR Signaling in Cultured Cancer Cells can Be Upregulated by Lactate and Glutamine Metabolism The combination of rapamycin plus sunitinib treatment for 1–2 weeks reproducibly elicited tumor regression, characterized by widespread necrosis and fibrosis, and...
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