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Eric Brown on Muck Rack

Eric Brown

McMaster University
As seen in: Nature, Clinical Pediatrics, BMJ Open, Eyes on Earth, Journal of Epidemiology and Community Health, PNAS, The BMJ, Science Magazine, BioRxiv, Cell Chemical Biology and
Biomedical scientist, Professor, researcher and leader of the ‘Brownies’ who are looking for new ways to kill superbugs.
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Articles

Ontong Java Plateau formed by a thermochemical mantle plume

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By Jinchang Zhang, Xubo Zhang, Shuangshuang Chen, Eric Brown, Jiangyang Zhang, Jian Lin, Rui Gao, William Sager, Jun Korenaga
| Nature Verified
Abstract The Ontong Java Plateau, mainly emplaced during the Early Cretaceous on the Pacific Plate, is the most voluminous extant oceanic plateau. The exceptional volume and flux of magma that formed this plateau is widely thought to result from melting induced by a hot, buoyant mantle plume head; however, a purely thermal plume predicts uplift to above sea level, inconsistent with the plateau’s mostly submarine emplacement.
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Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi

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By Xuefei Chen, H. Diessel Duan, Michael J Hoy, Kalinka Koteva, Michaela Spitzer, Allison K. Guitor, Emily Puumala, Aline A Fiebig, Guanggan Hu, Bonnie Yiu, Sommer Chou, Zhuyun Bian, Yeseul Choi, Wenliang Wang, Sheng Sun, Nicole Robbins, Anna Floyd Averette, Michael Cook, Ray Truant, Lesley T. MacNeil, Eric Brown, James W. Kronstad, Brian K. Coombes, Leah Cowen, Joseph Heitman, Huilin Li, Gerard Wright
| Cell Press Verified
Keywords Cryptococcus Candida auris antifungal natural product fungal resistance flippase Apt1-Cdc50 synergy echinocandin butyrolactol A Get full text access Log in, subscribe or purchase for full access. References 1. Iliev, I.D. ∙ Brown, G.D. ∙ Bacher, P. ... Focus on fungi Cell. 2024; 187:5121-5127 2. Denning, D.W. Global incidence and mortality of severe fungal disease Lancet Infect. Dis. 2024; 24:e428-e438 3. Brown, G.D. ∙ Denning, D.W. ∙ Gow, N.A.R. ... Hidden Killers: Human Fungal Infections Sci.
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Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation

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By Peng Tan, Alok Jaiswal, Shane Murphy, Eric Brown
| Science Magazine Verified
Editor’s summary Enteric neurons of the intestine play a major role in regulating intestinal physiology. Tan et al. characterized the effect of microbiota and inflammation on the enteric nervous system in mice. The authors integrated single-cell transcriptomics across three intestinal regions with in vivo functional perturbation to uncover how microbial cues and immune signals reshape inhibitory motor neuron states and sensory neuron plasticity.
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