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Articles by Eric Westhof
Global and specific mechanisms stimulate mistranslation in cancer
Abstract Tryptophan codon-specific mistranslation, in the form of ribosomal frameshifting and tryptophan-to-phenylalanine (W > F) codon reassignments (substitutants), is induced in cancer cells by the limiting level of tryptophan imposed by anti-tumour immunity. While the oncogenic mitogen-activated protein kinase pathway drives frameshifting, whether substitutants are genetically regulated remains unknown.
Catalytic and regulatory basis of tRNA t 6 A modification by the KEOPS complex
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Abstract N6-threonylcarbamoyladenosine (t6A) at tRNA position 37 is essential for translational fidelity and cellular homeostasis. The multi-subunit KEOPS complex catalyzes t6A formation in Archaea and Eukarya. Here we present cryo-EM structures of C. elegans KEOPS in its apo and tRNA-bound states. tRNA binding induces concerted conformational rearrangements, distorting the anticodon loop to project A37 into the Kae1 active site. Kae1 recognizes the conserved G10–C25 pair and 36-UAA-38 motif.
By Li Zhou Verified, Zelin Zhang, Mengqi Jin, Eric Westhof, Dongsheng Lei, Wenhua Zhang, Dengmiao Xie
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Nature
Verified
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
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By Miguel A. Garcia-Campos, Joe Georgeson, Ronit Nir, Robert Reichelt, Kristin A. Fluke, Donna Matzov, Vinithra Iyer, Brett W Burkhart, Lauren M Lui, Anatoly Kustanovich, Felix Grunberger, Supuni Thalalla-Gamage, Shereen A. Howpay-Manage, Milan Gerovac, Nicolas Alexandre, Yuko Nobe, Manoj Perera, Alexander Apostle, Shiyue Fang, Sebastian Glatt, Ghil Jona, Jörg Vogel, Masato Taoka, Jordan Meier, Eric Westhof, Thomas J. Santangelo, Dina Grohmann, Moran Shalev-Benami, Schraga Schwartz, Sébastien Ferreira-Cerca
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Cell Press
Verified
The RNA‐Puzzles Assessments of RNA‐Only Targets in CASP16
1 Introduction The 2024 Critical Assessment of protein Structure Prediction (CASP), CASP16, set of experiments was different from the previous one, CASP15 [1], in several aspects. First, there was an increase in the total number of targets as well as in the diversity of targets. Second, some of the targets were very large compared to previous runs in CASP or RNA-Puzzles [2-6].
RNA-Puzzles Round V: blind predictions of 23 RNA structures - Nature Methods
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Abstract RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predicted by modeling groups before publication of the experimental structures. We report a large-scale set of predictions by 18 groups for 23 RNA-Puzzles: 4 RNA elements, 2 Aptamers, 4 Viral elements, 5 Ribozymes and 8 Riboswitches.
By Yagoub Adam, Robert T. Batey, Eugene F. Baulin, Janusz M Bujnicki, Kristy A. Carpenter, Wah Chiu, Naba Krishna Das, Rhiju Das, Wayne Dawson, Frank DiMaio, Feng Hua Ding, Nikolay V. Dokholyan, Ron O. Dror, Adrian R. Ferré-D’Amaré, Caleb Geniesse, Horacio V. Guzman, Lin Huang, Farhang Jaryani, Astha Joshi, Masha Karelina, Sebastian Kmiecik, Rachael C Kretsch, Jun Li, Marcin Magnus, S. Naeim Moafinejad, Sunandan Mukherjee, Grigory I Nikolaev, Chandran Nithin, Alberto Perez, Alberto Pérez, Joseph A. Piccirilli, Almudena Ponce-Salvatierra, Ramya Rangan, Aiming Ren, Joanna Sarzynska, Congzhou Mike Sha, Filip Stefaniak, Krishna C. Suddala, Marta Szachniuk, Raphael J.L. Townshend, Jian Wang, Wenkai Wang, Yi Xiao, Jianyi Yang, Jinwei Zhang, Tomasz Zok, Eric Westhof, Deepak Koirala, Radosław Pluta, Lukasz Popenda
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Nature
Verified
Marc van Regenmortel, personal recollections on a forward‐thinking editor
Marc van Regenmortel's career in virology started in Schaarbeek, a neighborhood of Brussels, where he was born. It just happens that one of the authors (EW) was born in Uccle, another neighborhood of Brussels.
Evaluation of the stereochemical quality of predicted RNA 3D models in the RNA-Puzzles submissions
Evaluation of the stereochemical quality of predicted RNA 3D models in the RNA-Puzzles submissions Francisco Carrascoza, Maciej Antczak, Zhichao Miao, Eric Westhof, Marta Szachniuk bioRxiv 2021.08.22.457258; doi: https://doi.org/10.1101/2021.08.22.457258
Comment enseigner les SVT face aux fondamentalismes ?
Il y a un mois, l’horreur de l’assassinat de Samuel Paty révélait la difficulté d’enseigner la citoyenneté, mais aussi l’exposition des porteurs des messages laïques et civiques face au fondamentalisme religieux. Au-delà de la sidération, nous devons globalement repenser l’éducation des plus jeunes, dont certains tournent le dos au message de la République. D’autres enseignements sont aussi touchés dans leur capacité à former nos enfants.
Crystal structures of a group II intron lariat primed for reverse splicing
Group II in trons are mobile genetic elements found in all domains of life. They are large ribozymes that can excise themselves from host RNA. Costa et al. determined the structure of an excised group II intron in its branched conformation. This conformation is comparable to the branched “lariat” seen during the splicing of nuclear RNA transcripts. The lariat conformation helps assemble the group II active site for the reverse splicing reaction.
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