Erin Shannon on Muck Rack

Erin Shannon

Olympia
As seen in: Wiley Online Library, MDPI, Puget Sound Business Journal, The Seattle Times, Science Magazine, Cell Press, Cell Reports Medicine, The Spokesman-Review, The American Spectator, Accounting Today and
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Articles

Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss

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By Karolin Voßgröne, Sabrina Y. Camp, Haiyan Chu, Michael S. Cuoco, Amanda Garza, Sherin Xirenayi, Ziad Bakouny, Eddy Saad, Jad El Masri, Erica Pimenta, Kevin Meli, Chris Labaki, Breanna M. Titchen, Yun Jee Kang, Jack Horst, Erin Shannon, Rachel Trowbridge, Karla Helvie
| Science Magazine Verified
Abstract Transcriptional programs in renal cell carcinoma (RCC) have been linked to tumor heterogeneity and clinical outcomes, but analogous efforts to define chromatin programs shaping disease biology have been limited. Here, we generated single-cell ATAC-seq profiles from patients with RCC and integrated them with three previously published datasets to identify chromatin programs in tumor cells.
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Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma

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By Kevin Bi, Soki Kashima, Sabrina Y. Camp, Kevin Meli, Eddy Saad, Breanna M. Titchen, Chris Labaki, Ziad Bakouny, Erica Pimenta, Jihye Park, Erin Shannon, Jingxin Fu, Sherin Xirenayi, Jack Horst, Lotus Lum, Jeffrey J. Ishizuka, Toni K. Choueiri, David Braun
| Cell Press Verified
Keywords renal cell carcinoma immunotherapy immunotherapy resistance cancer immunology tumor immunology interferon signaling IFNs myeloid cells tumor-associated macrophages Introduction Immune checkpoint blockade (ICB) has become a crucial component of first-line management of advanced renal cell carcinoma (RCC).1,2,3,4,5,6 However, RCC immunobiology is distinct from that of other immunotherapy-responsive cancer types.
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Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma

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By Josephine Yates, Camille Mathey-Andrews, Jihye Park, Amanda Garza, Andréanne Gagné, Samantha Hoffman, Kevin Bi, Breanna M. Titchen, Connor Hennessey, Matthew Carnes, Erin Shannon, Sabrina Y. Camp, Shweta Kiran Cavale, Zhixin Li, Akhouri Kishore Raghawan, Agnieszka Kraft, Genevieve M. Boland, Andrew J. Aguirre, Nilay S. Sethi, Valentina Boeva, Joshua Remland, Siddhi Balamurali
| Cell Reports Medicine Verified
Keywords esophageal adenocarcinoma gastrointestinal cancer computational biology epigenetics transcriptomics spatial transcriptomics single cell oncology bioinformatics Introduction Esophageal adenocarcinoma (EAC) is believed to arise from Barrett’s esophagus, an uncommon metaplastic condition.1,2,3,4,5,6,7 EAC is exceptionally lethal, with a 5-year survival rate of less than 5% for patients with non-resectable disease or detectable metastases, representing over half of diagnosed patients.7,8...
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