In 1996, highly pathogenic avian influenza (HPAI) A(H5N1) virus was first isolated from a domestic goose in Guangdong province, China.[ [1] H5N1 avian influenza in China. ] Since then, it has been identified in other poultries and wild birds with spillover into humans in over 60 countries, including United States of America (US), United Kingdom and Canada.