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Talimogene laherparepvec and atezolizumab in HER2-negative breast cancer following neoadjuvant chemotherapy: a window-of-opportunity phase II trial (SOLTI-1503 PROMETEO) | Nature Communications

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By Tomás Pascual, Maria Espie Vidal, María Vidal Verified, Juan M. Cejalvo, Estela Vega, Esther Sanfeliu, Guillermo Villacampa, Sergi Ganau, Esther Zamora, Ignacio Miranda, Ana Delgado, Begoña Bermejo, Elia Seguí, Manel Juan, Patricia Galván, Samyukta Chillara, Patricia Villagrasa, Adam D. Pfefferle, Mafalda Oliveira, Charles M. Perou, Aleix Prat, Fara Brasó-Maristanty, Xavier Gonzàlez-Farré, Constandina E. O’Connell, Juan M. Ferrero-Cafiero
| Nature Verified
Abstract This single-arm, phase II, preoperative window-of-opportunity trial (ClinicalTrials.gov Identifier: NCT03802604) investigated the efficacy and safety of talimogene laherparepvec (T-VEC), an oncolytic virus, with atezolizumab, an anti–PD-L1 antibody, in patients with breast cancer and radiologically and pathologically confirmed residual disease prior to surgery.
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