Ethan Lange

1Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 2Center for Computation and Genomic Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 4Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA 5The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at...

Keywords transcriptome prediction models transcriptome-wide association study functional annotation multi-ancestry peripheral blood mononuclear cells PBMCs RNA-seq omnibus approach Introduction Although large-scale genome-wide association studies (GWASs) have identified numerous genetic variants associated with complex human diseases or traits, the inference from identified genetic variants to candidate genes remains challenging.

Keywords polygenic risk score equity diversity Introduction As genomic technologies spur progress in several areas of precision medicine, inequity in translating these advances to diverse groups has become evident.