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Ethan Trevor Suwandi on Muck Rack

Ethan Trevor Suwandi

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Articles

Ameloblastin amphipathic helix motif mediates ameloblast polarization and prismatic enamel formation

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By Jing Cai, Derk Joester, Natalie C. Kegulian, Edwin Sarkisians, Marziyeh Aghazadeh, Simon Webster, Janet Moradian-Oldak, Gayathri Visakan, Rucha Arun Bapat, Ethan Trevor Suwandi
| Nature Verified
Abstract Ameloblastin (Ambn) is a tooth-specific multifunctional protein essential for enamel biomineralization and the formation of its prismatic microstructure. To examine the function of the evolutionarily conserved cell-binding Ambn amphipathic helix (AH) motif, we deleted the hydrophobic residues within the Ambn AH motif in genetically engineered mice. Enamel in the homozygous (AmbnΔL76-P86) mutants had normal thickness but was hypo-mineralized and lacked prismatic structure.
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