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Etnik Sheremeti on Muck Rack

Etnik Sheremeti

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Articles

Generation of a novel knock-in mouse line expressing oncogenic Kit D814V in the hematopoietic stem cell compartment as a preclinical model for systemic mastocytosis

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By Alina Makeeva, Tiago Fonseca, Ewelina M. Bartoszek, Pawel Pelczar, Martina Konantz, Karin Hartmann, Simona Stivala, Elena Ratti, Etnik Sheremeti, Laetitia Clauss, Marc Usart
| Nature Verified
Abstract Research in mastocytosis, characterized by clonal expansion of mast cells (MC), and driven by the KIT D816V mutation in >90% of patients, has been hampered by the lack of in vivo models. Here, we describe a novel knock-in mouse line expressing Kit D814V (murine homolog to human KIT D816V) in the hematopoietic compartment by Scl-CreER-mediated recombination.
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